Risk Factors and Prevalence of Mother to New-Born Transmission of Carbapenemase Producing Enterobacteriaceae in Two Hospitals in Yaounde, Cameroon

Background: In African countries, where the burden of neonatal sepsis is highest, spread Carbapenemases Producing Enterobacteriaceae (CPE) in community, potentially contributing to mortality, a public health concern. The transmission routes are not well defined, particularly possible key role played by pregnant women. aim this study was understand acquisition CPE Yaounde, Cameroon. Methods: A transversal analytical conducted an urban area. Maternal stool samples during delivery and first from their new-born were collected cultured isolate Enterobacteria. After isolation, characterization using API20E identification system, antibiotic susceptibility testing performed according Antibiogram Committee French Society Microbiology. detection done on each carbapenem-resistant strain Modified Hodge Test (MHT) classification synergy tests with different inhibitors. Results: Out 55 isolates identified, Escherichia coli most encountered bacteria both mothers (n = 18, 50.00%) infants 11, 57.89%). Class B D carbapenemases found infants. estimated prevalence vertical our study, 10% 12). Logistic regression showed that carriage new-borns independently associated presence greenish amniotic fluid (OR 7.33, p 0.0001 OR 4.09, 0.0086 new-borns). Conclusion: Our results highlight non-negligeable women CPE.